Osomatsu-kun (1988)

The would-be hijinks of the mischievous Matsuno sextuplets are hijacked from episode one by colorful buck-toothed con man Iyami and Chibita, his bald munchkin sidekick. Nearly every episode is a standalone comedy cavalcade with the above cast as well as other quirky locals who show up in a number of different roles as the series shifts effortlessly...